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Mutect2 out of memory - not enough java heap space
I am running Mutect2 on whole genome sequencing and have run into an error with java. It seems to be running out of heap space towards the end of the run. I plan to add more with the -Xmx option and also spread the jobs out with intervals. However, I am wondering if there is a way to predict or determine how much heap space is actually needed for a Mutect2 run.