Test-drive the GATK tools and Best Practices pipelines on Terra

Check out this blog post to learn how you can get started with GATK and try out the pipelines in preconfigured workspaces (with a user-friendly interface!) without having to install anything.

How to get best performance in Merging 6K samples using CombineGVCFs and GenotypeGVCFs (GATK 4.0.9)

I am looking for the right practices in merging 6K samples using CombineGVCFs and GenotypeGVCFs to get the best performance. I don't see Spark appended Suffix for these, does that mean these methods can't make use of spark?

I also came across some old threads on plans in bringing tileDB in 4.0 version, which could improve the performance. How can I make use of tileDB?

PS: I generated the gvcfs using HaplotypeCallerSpark in gatk4


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