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DepthOfCoverage takes many hours to run
I am using DepthOfCoverage on a targeted sequencing bam of 400 mbs, reading from hg19 (3 gbs), with an Intel core i3 2.0 ghz processor and 4 gbs of RAM. The remaining hours for completion are almost 60. How should I upgrade my system in order to make it run considerably faster ? My total file list is over 100 BAMs.