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Test-drive the GATK tools and Best Practices pipelines on Terra
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How can MutSigCV be applied to germline mutation driver gene discovery?
we only have snp data(vcf format) from normal sample of the normal people without paired tumor sample. I have translated the vcf format data to the MAF data(any info about tumor sample were set null or unknown, while the normal sample info (Matched_Norm_Sample_Barcode) were set as patient id). However, when I run the Mutsig, it came out the error: MutSig is not applicable to single patients. However, my data do from multiple patient. What would be the problem? By the way, the log also has following NOTE: 1064544/1064680 mutations were outside the category set. Excluding them. Is the problem came from the format of the transformed MAF? Do I need to place the Matched_Norm_Sample_Barcode to the Tumor_Sample_Barcode or do I need to do other things? Thanks!