If you happen to see a question you know the answer to, please do chime in and help your fellow community members. We appreciate your help!
Test-drive the GATK tools and Best Practices pipelines on Terra
Check out this blog post to learn how you can get started with GATK and try out the pipelines in preconfigured workspaces (with a user-friendly interface!) without having to install anything.
PhaseByTransmission: Small sample size
I have 10 trios (unaffected father, unaffected Mother, and affected Child) and I want to extract de novo, autosomal recessive, and com. heterozygous variants. I want to use PhaseByTransmission and I have the pedigree information. My question is, can I use PhaseByTransmission for small number of trios (10 trios)? Could it be an issue if sample size is small? Can I run PhaseByTransmission for each trio separately?
Thanks in advance.