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PhaseByTransmission: Small sample size

newbeenewbee USAMember

Hello,
I have 10 trios (unaffected father, unaffected Mother, and affected Child) and I want to extract de novo, autosomal recessive, and com. heterozygous variants. I want to use PhaseByTransmission and I have the pedigree information. My question is, can I use PhaseByTransmission for small number of trios (10 trios)? Could it be an issue if sample size is small? Can I run PhaseByTransmission for each trio separately?

Thanks in advance.
Newbee

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