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Clean version of dbSNP in the GATK resource bundle

Hi I understand that version 129 of dbSNP is considered clean and does not share data from other databases such as 1000G projects.

  • What steps of the variant calling in WGS/WES analysis can be affected by using GATK resource bundle provided dnSNP138 after excluding the sites released after version 129 versus using all variants in the dbSNP version 138 ?

  • Are there any specific drawbacks of using latest dbSNP version 150 ?

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by Sheila

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