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We have a problem with GATK DepthOfCoverage, it is running too slow. With default parameters, it took 12 hours on Amazon c4.2xlarge instance for a BAM of 125MB. We are running at this moment another task on c4.8xlarge, with -nt parameter set to 36 and --OmitIntervalStatistics, but it seems multithreading does not work. Can someone help with this? Or maybe suggest some other tool with similar funcionality?