Reversions: an Algorithm issue
Since this is an algorithm question that covers both types of MuTect, I'd rather raise it here.
I have noticed the variant calling model in MuTect seems to require AF[TUMOR] > AF[NORMAL] to be called. This implies that a reversion/ back mutation, i.e. AF[TUMOR] < AF[NORMAL], will not be called. Is there any rationale to this?