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Interpreting Allele frequency equal to 1.0

ambi1999ambi1999 United KingdomMember

Hi,

In the following vcf file, the AF allele frequency of ALT allele is 1.0. Does it mean that it is not a true SNP of interest? Does it also mean that ALT allele always occurs and REF allele never occurs in the population?

Also not sure how allele count AC=37 is being calculated.

Chr1 pos=565286, REF=C, ALT=T, Info AC=37; AF=1.0 Format GT:AC:AF:NC Child=1:11:1.0:+T=4,-
T=7 mother=1:26:1.0:+T=8,-T=18,

Cheers,
Ambi

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