VQSR omni truth or not?
Hi, I am working with b37 datasets from resource bundle. I am finding conflicting advise through various internet resources, on using 1000G_omni2.5.b37.vcf as truth or not. While current broad best practices identify this as truth=true for VariantRecalibrator, many other pipelines and resources mention otherwise.
Could you please clarify which is the case and whether b37 vs b38 has any impact on this decision.