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VQSR omni truth or not?

Hi, I am working with b37 datasets from resource bundle. I am finding conflicting advise through various internet resources, on using 1000G_omni2.5.b37.vcf as truth or not. While current broad best practices identify this as truth=true for VariantRecalibrator, many other pipelines and resources mention otherwise.
Could you please clarify which is the case and whether b37 vs b38 has any impact on this decision.

Best Answer


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