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panel of normals tissue origin

2nelly2nelly SwitzerlandMember

Hi all,

I am thinking to build a panel of normal samples using MuTect2 in order to use it for somatic variant calling in mouse tumors. So, my question is: can this panel be a fusion of samples coming from different types of tissue or should come from the same type? Suppose doesn't matter.

Thank you in advance!

Issue · Github
by Sheila

Issue Number
769
State
closed
Last Updated
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Array
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vdauwera

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  • 2nelly2nelly SwitzerlandMember

    I was thinking to use it in order to exclude rare germline variants.
    Of course all my candidate samples for PON are coming from healthy mice.

    So, thanks for your reply Geraldine
    Keep up the good work!

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