Our staff will be observing the holiday and will be unavailable from 22nd to 25th November. This will cause a delay in reaching out to you and answering your questions immediately. Rest assured we will get back to it on Monday November 26th. We are grateful for your support and patience.
Have a great holiday everyone!!!
VQSR for single sample exome/targeted regions
I read on the best practices slides that I should not use VQSR if the cohort is small. I only one sample for a single individual. I was wondering how useful it is to perform VQSR on this sample by using the GVCFs from 1000G? Am I losing a lot by not doing VQSR step for a single sample? I have some parameters in mind that I want the final VCF to satisfy: Min Q and Min depth.