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VQSR - overlapping training sets


when I have multiple training sets for VQSR,
what happens with overlapping variants between these two sets?
Especially when the two sets have different priors attached.

Example from Best Practices:
I have HapMap with prior Q15 and
1000G with prior Q10.
How will a variant influence the model when being in both sets?
I would expect that only the highest prior will be used.


Best Answer


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