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Apply VQSR to variants called by other tools
Hi, I have several variant files that were generated by other calling tools with some annotations not defined by GATK. I wonder if I can also apply VQSR on these dataset restricting to those exclusive annotations (using "-an"). Is there any drawback for this application?
Besides, I saw somewhere that fitting only a single Gaussian distribution to each annotation. Is this a proper way to perform variant recalibration?