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Parallelize processing individual samples for Variant calling

pagarwal14pagarwal14 Durham, NCMember

I have 190 samples that I am running through the GATK DNAseq pipeline following the Best Practices. Since only a few genes have been sequenced for each sample, the alignment files are very small (0.5 GB BAM files), but even then processing each samples takes about 3 hours. Is there a way to parallelize the processing of the individual samples on a mutli-core machine (since processing each sample is independent of each other it should not make a difference). There is a feature in Python using Pool in the multiprocessing module that could be used. I tried it but it does not seem to work for me. Does the GATK team have any guidance or information on this issue.

  • Pankaj

Best Answer


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