I have performed BaseRecailbrator using GATK-3.2-2 . The size of the bam file is double the size of realigned_fixmate.bam. I read in one of the posts in this forum that it could be because of retaining the original and reclaibrated quality scores. And mentioned that the latest version will by default exclude original scores and retain reclaibrated scores.
Im using the latest version and still gets double the size of the original bam. Could someone comment on this. Thanks