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can any body help me with these lines in GATK Paper and how this problem is tackled in GATK
A framework for variation discovery and genotyping using next-generation DNA sequencing data
Previous approaches have relied on filtering SNP calls that have characteristics outside of their normal ranges, such as those occurring at sites with too much coverage, or by requiring non-reference bases to occur on at least three reads in both synthesis orientations
the main confusion is around
bases to occur on at least three reads in both synthesis orientations
i will appreciate if any image can help