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value of joint genotyping in trio's
We're looking into modernizing our workflows and I was wondering if there's much value to joint genotyping very small cohorts (e.g. trio's), as opposed to comparing results of three separate samples next to each other.
I'd like to know how much this could affect quality scores and actual genotypes etc. I can see the value for large cohorts, but I have my doubts with something as small as 3 individuals