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Does the Broad still recommend aligning WXS/WES data to b37/hg19?

pwaltmanpwaltman New York, NYMember

According to the article on the the resource bundle (, you still recommend aligning to b37/hg19 for WXS/WES data (with either hg38 or b37/hg19 for WGS data). However it appears that that recommendation is over 2 years old (the page states that that recommendation is from August 2016).

Do you still recommend using b37/hg19 for WXS/WES data? I'm asking because it appears that a number of the articles on the site assume that one is working with bams that have been aligned to hg38, e.g. this tutorial on using mutect2:

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