The frontline support team will be slow on the forum because we are occupied with the GATK Workshop on March 21st and 22nd 2019. We will be back and more available to answer questions on the forum on March 25th 2019.
I'm trying to call genotypes on ~160 S. cerevisiae genomes by going calling. When I tried to do it on the whole genome with a single command, it would run out of memory (even with 48G provided). Now I'm doing it one chromosome at a time:
gatk-126.96.36.199/gatk --java-options "-Xmx48G" GenotypeGVCFs -R Saccharomyces_cerevisiae.R64-1-1.dna.toplevel.fasta -V combined_variants.vcf.gz -O called_genotypes_II.vcf.gz -ploidy 1 -L II
It initially appears to make progress, for the first 25 minutes, but I've had no console activity for the last 90 minutes. Looking at the CPU monitor, it just shows periodic spikes, but not sustained activity. I even tried it over night, with exactly the same behavior - i.e. 25 minutes of console updates then nothing. Chromosome I worked fine, but II never completes. Are there other similar reports?