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Interpretation of LOD scores for CrosscheckFingerprints
I am using
CrosscheckFingerprints to compare sets of samples from the same individual (including tumor and non-tumor samples). My understanding is that LOD scores > 5 or so strongly indicate that the samples are from the same individual. From the GATK poster here I conclude that LOD scores typically range from 0 to 100. Nevertheless, I am getting what seems like LOD scores > 5000 across most of my samples and have not seen any LOD scores in the 0-100 range, ie.
- Should I take the log10 of these LOD scores to get the actual LOD score? If I do this however, the LOD scores are on the low end (3.5 - 4.5) though these samples are definitely from the same individual (those marked as expected match indicate multiple readgroups from the same sample) and a very high LOD score is expected, but perhaps not in the 5000+ range?
- What's the difference between LOD_SCORE_TUMOR_NORMAL and LOD_SCORE_NORMAL_TUMOR and when to use which? Depending on which sample is right and which is left in the comparison? What if both left and right side of the comparison are tumor samples?