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BQSR and Novaseq quality scores

TestorTestor GermanyMember

Dear all,
we recently bought an Illumina Novaseq instrument and as a first project sequenced some human whole genomes.
Since the Novaseq only has 4 quality scores (2, 11, 25 and 37) I was wondering if BQSR makes any sense. Could you please be so kind comment on this issue?

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