ReadBacked phasing vs Trio phasing?

I think I understand the technical difference. But in terms of phasing quality, how does one compare to the another? Are there any publications/reports/blog posts comparing the two? Is there some quantifiable metric that shows how different the estimates are?

Issue · Github
by Sheila

Issue Number
2896
State
closed
Last Updated
Assignee
Array
Closed By
vdauwera

Best Answer

Answers

  • SheilaSheila Broad InstituteMember, Broadie, Moderator admin

    @rmf
    Hi,

    Read backed phasing does physical phasing based on the variants in the reads. The other does phasing based on the known genotypes of the parents. Considering that we have only retained tools that do physical phasing (read backed phasing), I think the team must be pretty confident that type is good enough.

    I have to check with the team and get back to you on some good publications.

    -Sheila

Sign In or Register to comment.