MuTect2 beta --germline_resource file
I'm new in using MuTect2
I'm a bit confused that the gnomAD file provided on gnomad.broadinstitute.org/downloads is about three times larger than the gnomAD file provided on ftp://firstname.lastname@example.org/bundle/beta/Mutect2/af-only-gnomad.raw.sites.b37.vcf.gz ?
is there any difference between these two files ? could the difference affect the output of MuTect2??
Thx in advance