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# VQSR Training

Member Posts: 16
edited October 2012

When performing VQSR, the data set has its variants overlapped with the training set, may I know if all the overlapped variants are used in the training or is it down sampled?

Post edited by Geraldine_VdAuwera on
Tagged:

• Dev Posts: 122 ✭✭✭

Hi atks,

There isn't any downsampling of the training variants however there is some filtering that is done. By looking at the 1D annotation distributions, extreme outliers are removed from the training set. This behavior is controlled with the --stdThreshold argument to VariantRecalibrator.

I hope that helps,

There isn't any downsampling of the training variants however there is some filtering that is done. By looking at the 1D annotation distributions, extreme outliers are removed from the training set. This behavior is controlled with the --stdThreshold argument to VariantRecalibrator.