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Does HaplotypeCaller cost a lot of RAM?

skblazerskblazer Member Posts: 18
edited September 2012 in Ask the GATK team

I tried to run several HaplotypeCaller jobs simultaneously on a node. But sometimes, not all the time, they caused the nodes collapse. I noticed that HaplotypeCaller sometimes occupied tens of GB of memory, is this normal? The average depth for my samples is 30x-50x.

Post edited by Geraldine_VdAuwera on
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