Bug Bulletin: we have identified a bug that affects indexing when producing gzipped VCFs. This will be fixed in the upcoming 3.2 release; in the meantime you need to reindex gzipped VCFs using Tabix.
VQSR on GENOTYPE_GIVEN_ALLELES mode
When using GENOTYPE_GIVEN_ALLELES with HaplotypeCaller, which uses EMIT_ALL_SITES and so has many calls where the entire cohort is nonvariant, do these reference only sites have to be filtered out before calling VQSR?
0 · ·