Cutoff for Application of Yates Correction in Base Quality Recalibration

PipePlumber

What is the criterion (or criteria) for applying the Yates correction to the empirical base qualities in the base quality recalibration?

Thanks!

rpoplin

Simple-- it is always applied. It is very important when some covariate bins are rarely observed but it is just a drop in the bucket when there is a lot of data.

PipePlumber

Thank you! Have a good holiday!