Bug Bulletin: we have identified a bug that affects indexing when producing gzipped VCFs. This will be fixed in the upcoming 3.2 release; in the meantime you need to reindex gzipped VCFs using Tabix.

XHMM

The XHMM (eXome-Hidden Markov Model) C++ software suite calls copy number variation (CNV) from next-generation sequencing projects, where exome capture was used (or targeted sequencing, more generally). Specifically, XHMM uses principal component analysis (PCA) normalization and a hidden Markov model (HMM) to detect and genotype copy number variation (CNV) from normalized read-depth data from targeted sequencing experiments. Please see the XHMM website for more information.